Graves' disease and insulin-dependent diabetes mellitus in idiopathic Addison's disease.
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چکیده
منابع مشابه
A conformation-dependent epitope in Addison's disease and other endocrinological autoimmune diseases maps to a carboxyl-terminal functional domain of human steroid 21-hydroxylase.
Idiopathic Addison's disease develops as a consequence of autoimmune destruction of steroid-producing cells in the adrenal gland. A major autoantigen is 21-hydroxylase (21OH; P450c21), which is involved in the biosynthesis of cortisol and aldosterone in the adrenal cortex. We selected a number of functionally important 21OH amino acid substitutions, found in patients with congenital adrenal hyp...
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Autoantibodies (Abs) to steroid 21-hydroxylase (21-OH) are a major component of adrenal cortex Abs and are characteristic of autoimmune Addison's disease. We have developed a new method for measuring Abs to 21-OH based on 125I-labeled recombinant human 21-OH produced in yeast. With this assay, 21-OH Abs were detected in 43 of 60 (72%) sera from patients with isolated Addison's disease, 11 of 12...
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SELBY, J.B. (1962) Addison's disease associated with diabetes mellitus. Amer. Practit. 13, 347. SOLOMON, N., CARPENTER, C.C.J., BENNETT, I.L. & HARVEY, A.McG. (1965) Schmidt's syndrome and coexistent diabetes mellitus. Diabetes, 14, 300. THORN, G.W., FARSHAM, P.H., PRUNTY, F.T.G., BERGNER, G.E. & HILLs, A.G. (1949) Clinical studies in Addison's disease. Ann. N. Y. Acad. Sci. 50, 646. TZAGOURINS...
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عنوان ژورنال:
- Postgraduate medical journal
دوره 68 799 شماره
صفحات -
تاریخ انتشار 1992